Résultats du segment 2 de l'événement O’Reilly Auto Parts 253 2021
21 février
Floride - Daytona Beach
Daytona International Speedway Road Course 5,81 km (3,61 mi)
| P | # | Pilote | Propriétaire | Moteur | Tours | Points | PP |
| 1 | 11 | Denny Hamlin | Joe Gibbs Racing | Toyota | 34 | 10 | 1 |
| 2 | 1 | Kurt Busch | Chip Ganassi Racing | Chevrolet | 34 | 9 | |
| 3 | 22 | Joey Logano | Team Penske | Ford | 34 | 8 | |
| 4 | 20 | Christopher David Bell | Joe Gibbs Racing | Toyota | 34 | 7 | |
| 5 | 19 | Martin Truex Jr. | Joe Gibbs Racing | Toyota | 34 | 6 | |
| 6 | 9 | Chase Elliott | Hendrick Motorsports | Chevrolet | 34 | 5 | |
| 7 | 24 | William Byron | Hendrick Motorsports | Chevrolet | 34 | 4 | |
| 8 | 41 | Cole Matthew Custer | Stewart-Haas Racing | Ford | 34 | 3 | |
| 9 | 16 | Anthony James Allmendinger | Kaulig Racing | Chevrolet | 34 | ||
| 10 | 18 | Kyle Busch | Joe Gibbs Racing | Toyota | 34 | 1 |